4omm

X-ray diffraction
1.9Å resolution

Crystal structure of the intertwined dimer of the c-Src tyrosine kinase SH3 domain mutant N113S

Released:
Source organism: Gallus gallus
Entry authors: Camara-Artigas A, Bacarizo J

Function and Biology Details

Reaction catalysed:
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Proto-oncogene tyrosine-protein kinase Src Chain: A
Molecule details ›
Chain: A
Length: 77 amino acids
Theoretical weight: 8.68 KDa
Source organism: Gallus gallus
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P00523 (Residues: 85-140; Coverage: 11%)
Gene name: SRC
Sequence domains: SH3 domain
Structure domains: SH3 Domains

Ligands and Environments


No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID14-4
Spacegroup: P6522
Unit cell:
a: 46.95Å b: 46.95Å c: 126.69Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.176 0.174 0.213
Expression system: Escherichia coli BL21(DE3)