4oml

X-ray diffraction
1.6Å resolution

Crystal structure of the intertwined dimer of the c-Src tyrosine kinase SH3 domain mutant Q128R

Released:

Function and Biology Details

Reaction catalysed:
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Proto-oncogene tyrosine-protein kinase Src Chain: A
Molecule details ›
Chain: A
Length: 78 amino acids
Theoretical weight: 8.82 KDa
Source organism: Gallus gallus
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P00523 (Residues: 85-141; Coverage: 11%)
Gene name: SRC
Sequence domains: SH3 domain
Structure domains: SH3 Domains

Ligands and Environments

2 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE BM16
Spacegroup: P6522
Unit cell:
a: 46.546Å b: 46.546Å c: 128.034Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.17 0.168 0.199
Expression system: Escherichia coli BL21(DE3)