4o42

X-ray diffraction
1.87Å resolution

Tandem chromodomains of human CHD1 in complex with influenza NS1 C-terminal tail dimethylated at K229

Released:

Function and Biology Details

Reaction catalysed:
ATP + H(2)O = ADP + phosphate
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Chromodomain-helicase-DNA-binding protein 1 Chain: A
Molecule details ›
Chain: A
Length: 194 amino acids
Theoretical weight: 22.94 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: O14646 (Residues: 268-443; Coverage: 10%)
Gene name: CHD1
Sequence domains: Chromo (CHRromatin Organisation MOdifier) domain
Structure domains: OB fold (Dihydrolipoamide Acetyltransferase, E2P)
Non-structural protein 1 Chain: B
Molecule details ›
Chain: B
Length: 15 amino acids
Theoretical weight: 1.82 KDa
Source organism: Influenza A virus (A/Hong Kong/5/1983(H3N2))
Expression system: Not provided
UniProt:
  • Canonical: Q38SQ2 (Residues: 216-230; Coverage: 6%)
Gene name: NS

Ligands and Environments

2 bound ligands:
1 modified residue:

Experiments and Validation Details

Entry percentile scores
X-ray source: rigaku fr-e
Spacegroup: P21212
Unit cell:
a: 110.068Å b: 46.057Å c: 46.4Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.19 0.189 0.221
Expression systems:
  • Escherichia coli BL21(DE3)
  • Not provided