X-ray diffraction
1.9Å resolution

Tandem chromodomains of human CHD1 in complex with Influenza virus NS1 C-terminal tail trimethylated at K229


Function and Biology Details

Reaction catalysed:
ATP + H(2)O = ADP + phosphate
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Chromodomain-helicase-DNA-binding protein 1 Chains: A, C
Molecule details ›
Chains: A, C
Length: 194 amino acids
Theoretical weight: 22.94 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
  • Canonical: O14646 (Residues: 268-443; Coverage: 10%)
Gene name: CHD1
Sequence domains: Chromo (CHRromatin Organisation MOdifier) domain
Structure domains: OB fold (Dihydrolipoamide Acetyltransferase, E2P)
Non-structural protein 1 Chains: B, D
Molecule details ›
Chains: B, D
Length: 15 amino acids
Theoretical weight: 1.83 KDa
Source organism: Influenza A virus (A/swine/Henan/1/2010(H3N2))
Expression system: Not provided
  • Canonical: P03495 (Residues: 216-230; Coverage: 6%)
Gene name: NS

Ligands and Environments

2 bound ligands:
1 modified residue:

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 19-ID
Spacegroup: P212121
Unit cell:
a: 48.557Å b: 92.248Å c: 110.043Å
α: 90° β: 90° γ: 90°
R R work R free
0.201 0.199 0.242
Expression systems:
  • Escherichia coli BL21(DE3)
  • Not provided