PDBe 4ntj

X-ray diffraction
2.62Å resolution

Structure of the human P2Y12 receptor in complex with an antithrombotic drug

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
P2Y purinoceptor 12; Soluble cytochrome b562 Chain: A
Molecule details ›
Chain: A
Length: 466 amino acids
Theoretical weight: 53.25 KDa
Source organisms: Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P0ABE7 (Residues: 23-128; Coverage: 100%)
  • Canonical: Q9H244 (Residues: 2-223, 224-342; Coverage: 100%)
  • nullnull
Gene names: HORK3, P2RY12, cybC
Sequence domains:

Ligands and Environments

3 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 23-ID-D
Spacegroup: C2
Unit cell:
a: 98.65Å b: 156.43Å c: 47.77Å
α: 90° β: 111.08° γ: 90°
R-values:
R R work R free
0.221 0.22 0.246
Expression system: Spodoptera frugiperda