4nqn

X-ray diffraction
1.73Å resolution

Crystal Structure of the bromodomain of human BRD9 in complex with a triazolo-phthalazine ligand

Released:
Source organism: Homo sapiens
Entry authors: Filippakopoulos P, Picaud S, Felletar I, Martin S, Fedorov O, von Delft F, Arrowsmith CH, Edwards AM, Bountra C, Knapp S, Structural Genomics Consortium (SGC)

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Bromodomain-containing protein 9 Chain: A
Molecule details ›
Chain: A
Length: 123 amino acids
Theoretical weight: 14.25 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q9H8M2 (Residues: 134-243; Coverage: 18%)
  • Best match: Q9H8M2-1 (Residues: 14-134)
Gene names: BRD9, UNQ3040/PRO9856
Sequence domains: Bromodomain
Structure domains: Bromodomain-like

Ligands and Environments

1 bound ligand:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU FR-E SUPERBRIGHT
Spacegroup: P212121
Unit cell:
a: 47.12Å b: 48.42Å c: 69.32Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.19 0.188 0.245
Expression system: Escherichia coli BL21(DE3)