4nng

X-ray diffraction
2.02Å resolution

Structural basis for targeting the ribosomal protein S1 of Mycobacterium tuberculosis by pyrazinamide

Released:

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
30S ribosomal protein S1 Chain: A
Molecule details ›
Chain: A
Length: 158 amino acids
Theoretical weight: 18.34 KDa
Source organism: Mycobacterium tuberculosis H37Rv
Expression system: Escherichia coli
UniProt:
  • Canonical: P9WH43 (Residues: 285-435; Coverage: 31%)
Gene names: MTCY01B2.22, Rv1630, rpsA
Sequence domains: S1 RNA binding domain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Spacegroup: P212121
Unit cell:
a: 52.133Å b: 56.031Å c: 65.342Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.209 0.207 0.26
Expression system: Escherichia coli