PDBe 4nb3

X-ray diffraction
1.35Å resolution

Crystal structure of RPA70N in complex with a 3,4 dichlorophenylalanine ATRIP derived peptide


Function and Biology Details

Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Replication protein A 70 kDa DNA-binding subunit, N-terminally processed Chains: A, B
Molecule details ›
Chains: A, B
Length: 123 amino acids
Theoretical weight: 13.5 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
  • Canonical: P27694 (Residues: 1-120; Coverage: 20%)
Gene names: REPA1, RPA1, RPA70
Sequence domains: Replication factor-A protein 1, N-terminal domain
Structure domains: Nucleic acid-binding proteins
ATR-interacting protein Chains: C, D
Molecule details ›
Chains: C, D
Length: 15 amino acids
Theoretical weight: 2.2 KDa
Source organism: Homo sapiens
Expression system: Not provided
  • Canonical: Q8WXE1 (Residues: 54-67; Coverage: 2%)
Gene names: AGS1, ATRIP

Ligands and Environments

No bound ligands

1 modified residue:

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 21-ID-D
Spacegroup: C2
Unit cell:
a: 90.145Å b: 46.803Å c: 78.792Å
α: 90° β: 120.64° γ: 90°
R R work R free
0.146 0.144 0.175
Expression systems:
  • Escherichia coli BL21(DE3)
  • Not provided