4lop

X-ray diffraction
2.05Å resolution

Structural basis of autoactivation of p38 alpha induced by TAB1 (Tetragonal crystal form)

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
Non-polymer only dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Mitogen-activated protein kinase 14 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 361 amino acids
Theoretical weight: 41.4 KDa
Source organism: Mus musculus
Expression system: Escherichia coli
UniProt:
  • Canonical: P47811 (Residues: 1-360; Coverage: 100%)
Gene names: Crk1, Csbp1, Csbp2, Mapk14
Sequence domains: Protein kinase domain
Structure domains:
TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 Chains: K, L, M, N
Molecule details ›
Chains: K, L, M, N
Length: 29 amino acids
Theoretical weight: 3.1 KDa
Source organism: Mus musculus
Expression system: Not provided
UniProt:
  • Canonical: Q8CF89 (Residues: 384-412; Coverage: 6%)
Gene names: Map3k7ip1, Tab1

Ligands and Environments

3 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I03
Spacegroup: P41
Unit cell:
a: 86.54Å b: 86.54Å c: 226.92Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.228 0.148 0.188
Expression systems:
  • Escherichia coli
  • Not provided