X-ray diffraction
1.95Å resolution

Structural basis of autoactivation of p38 alpha induced by TAB1 (Monoclinic crystal form)


Function and Biology Details

Structure analysis Details

Assembly composition:
Non-polymer only dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Mitogen-activated protein kinase 14 Chain: A
Molecule details ›
Chain: A
Length: 361 amino acids
Theoretical weight: 41.4 KDa
Source organism: Mus musculus
Expression system: Escherichia coli
  • Canonical: P47811 (Residues: 1-360; Coverage: 100%)
Gene names: Crk1, Csbp1, Csbp2, Mapk14
Sequence domains: Protein kinase domain
Structure domains:
TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 Chain: B
Molecule details ›
Chain: B
Length: 29 amino acids
Theoretical weight: 3.1 KDa
Source organism: Mus musculus
Expression system: Not provided
  • Canonical: Q8CF89 (Residues: 384-412; Coverage: 6%)
Gene names: Map3k7ip1, Tab1

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I03
Spacegroup: P21
Unit cell:
a: 43.34Å b: 73.58Å c: 59.19Å
α: 90° β: 91.15° γ: 90°
R R work R free
0.241 0.198 0.25
Expression systems:
  • Escherichia coli
  • Not provided