4lhz

X-ray diffraction
3.2Å resolution

Crystal structure of GTP-bound Rab8:Rabin8

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Ras-related protein Rab-8A Chains: A, B
Molecule details ›
Chains: A, B
Length: 186 amino acids
Theoretical weight: 21.26 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: P61006 (Residues: 1-184; Coverage: 89%)
Gene names: MEL, RAB8, RAB8A
Sequence domains: Ras family
Structure domains: P-loop containing nucleotide triphosphate hydrolases
Rab-3A-interacting protein Chains: C, D, E, F
Molecule details ›
Chains: C, D, E, F
Length: 78 amino acids
Theoretical weight: 8.98 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: Q96QF0 (Residues: 173-248; Coverage: 16%)
Gene names: RAB3IP, RABIN8

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X10SA
Spacegroup: C2221
Unit cell:
a: 81.337Å b: 165.561Å c: 167.263Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.279 0.278 0.309
Expression system: Escherichia coli BL21