4lcc

X-ray diffraction
3.26Å resolution

Crystal structure of a human MAIT TCR in complex with a bacterial antigen bound to humanized bovine MR1

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
Non-polymer only trimer (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Beta-2-microglobulin; Major histocompatibility complex class I-related gene protein Chain: C
Molecule details ›
Chain: C
Length: 392 amino acids
Theoretical weight: 45.27 KDa
Source organism: Bos taurus
Expression system: Trichoplusia ni
UniProt:
  • Canonical: C1ITJ8 (Residues: 19-295; Coverage: 87%)
  • Canonical: P01888 (Residues: 21-118; Coverage: 100%)
Gene names: B2M, MR1
Sequence domains:
Structure domains:
Ig-like domain-containing protein Chain: A
Molecule details ›
Chain: A
Length: 208 amino acids
Theoretical weight: 23.16 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q6P4G7 (Residues: 5-213; Coverage: 79%)
Gene name: TRA@
Sequence domains:
Structure domains: Immunoglobulins
T cell receptor beta constant 1 Chain: B
Molecule details ›
Chain: B
Length: 253 amino acids
Theoretical weight: 28.29 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P01850 (Residues: 1-129; Coverage: 73%)
Gene name: TRBC1
Sequence domains: Immunoglobulin C1-set domain
Structure domains: Immunoglobulins

Ligands and Environments

2 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 23-ID-D
Spacegroup: P212121
Unit cell:
a: 85.902Å b: 88.585Å c: 155.505Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.26 0.257 0.312
Expression systems:
  • Trichoplusia ni
  • Escherichia coli