4lc2

X-ray diffraction
1.65Å resolution

Crystal structure of the bromodomain of human BRPF1B

Released:
Source organism: Homo sapiens
Entry authors: Tallant C, Nunez-Alonso G, Savitsky P, Picaud S, Filippakopoulos P, von Delft F, Arrowsmith CH, Edwards AM, Bountra C, Knapp S, Structural Genomics Consortium (SGC)

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Peregrin Chain: A
Molecule details ›
Chain: A
Length: 116 amino acids
Theoretical weight: 13.7 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P55201 (Residues: 626-740; Coverage: 10%)
Gene names: BR140, BRPF1
Sequence domains: Bromodomain
Structure domains: Bromodomain-like

Ligands and Environments

2 bound ligands:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU FR-E SUPERBRIGHT
Spacegroup: P3221
Unit cell:
a: 60.835Å b: 60.835Å c: 63.679Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.177 0.174 0.22
Expression system: Escherichia coli BL21(DE3)