X-ray diffraction
0.98Å resolution

Human transketolase in covalent complex with donor ketose D-fructose-6-phosphate


Function and Biology Details

Reaction catalysed:
Sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate = D-ribose 5-phosphate + D-xylulose 5-phosphate
Biochemical function:
Cellular component:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Transketolase Chain: A
Molecule details ›
Chain: A
Length: 637 amino acids
Theoretical weight: 69.65 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
  • Canonical: P29401 (Residues: 1-623; Coverage: 100%)
Gene name: TKT
Sequence domains:
Structure domains:

Ligands and Environments

Cofactor: Ligand TDP 1 x TDP
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID14-4
Spacegroup: C2
Unit cell:
a: 113.76Å b: 85.88Å c: 72.99Å
α: 90° β: 125.31° γ: 90°
R R work R free
0.103 0.102 0.122
Expression system: Escherichia coli BL21(DE3)