PDBe 4k1e

X-ray diffraction
1.3Å resolution

Atomic resolution crystal structures of Kallikrein-Related Peptidase 4 complexed with a modified SFTI inhibitor FCQR

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Kallikrein-4 Chain: A
Molecule details ›
Chain: A
Length: 223 amino acids
Theoretical weight: 23.93 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9Y5K2 (Residues: 31-253; Coverage: 98%)
  • Best match: Q9Y5K2-2 (Residues: 1-110)
Gene names: EMSP1, KLK4, PRSS17, PSTS
Sequence domains: Trypsin
Structure domains: Trypsin-like serine proteases
Trypsin inhibitor 1 Chain: B
Molecule details ›
Chain: B
Length: 14 amino acids
Theoretical weight: 1.58 KDa
Source organism: Helianthus annuus
Expression system: Not provided
UniProt:
  • Canonical: Q4GWU5 (Residues: 40-53; Coverage: 45%)
Gene name: sfti1

Ligands and Environments

2 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: AUSTRALIAN SYNCHROTRON BEAMLINE MX2
Spacegroup: P21
Unit cell:
a: 39.78Å b: 63.306Å c: 41.181Å
α: 90° β: 115.66° γ: 90°
R-values:
R R work R free
0.141 0.14 0.17
Expression systems:
  • Escherichia coli
  • Not provided