PDBe 4k11

X-ray diffraction
2.3Å resolution

The structure of 1NA in complex with Src T338G

Released:
Source organism: Homo sapiens
Entry authors: Eck MJ, Yun CH

Function and Biology Details

Reaction catalysed:
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
Biological process:
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Proto-oncogene tyrosine-protein kinase Src Chain: A
Molecule details ›
Chain: A
Length: 448 amino acids
Theoretical weight: 51.21 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P12931 (Residues: 87-534; Coverage: 84%)
Gene names: SRC, SRC1
Sequence domains:
Structure domains:

Ligands and Environments

1 bound ligand:

1 modified residue:

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU
Spacegroup: P212121
Unit cell:
a: 50.96Å b: 72.72Å c: 171.98Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.199 0.196 0.246
Expression system: Spodoptera frugiperda