4jpz

X-ray diffraction
3.02Å resolution

Voltage-gated sodium channel 1.2 C-terminal domain in complex with FGF13U and Ca2+/calmodulin

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Fibroblast growth factor 13 Chains: A, E
Molecule details ›
Chains: A, E
Length: 192 amino acids
Theoretical weight: 21.61 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q92913 (Residues: 58-245; Coverage: 77%)
  • Best match: Q92913-2 (Residues: 5-192)
Gene names: FGF13, FHF2
Sequence domains: Fibroblast growth factor
Structure domains: Trefoil (Acidic Fibroblast Growth Factor, subunit A)
Sodium channel protein type 2 subunit alpha Chains: B, H
Molecule details ›
Chains: B, H
Length: 184 amino acids
Theoretical weight: 21.04 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q99250 (Residues: 1777-1937; Coverage: 8%)
Gene names: NAC2, SCN2A, SCN2A1, SCN2A2
Structure domains:
Calmodulin-1 Chains: C, I
Molecule details ›
Chains: C, I
Length: 149 amino acids
Theoretical weight: 16.85 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P0DP23 (Residues: 1-149; Coverage: 100%)
Gene names: CALM, CALM1, CAM, CAM1
Sequence domains: EF-hand domain pair

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 24-ID-C
Spacegroup: C2
Unit cell:
a: 153.133Å b: 86.106Å c: 109.399Å
α: 90° β: 100.9° γ: 90°
R-values:
R R work R free
0.214 0.212 0.246
Expression system: Escherichia coli