PDBe 4jop

X-ray diffraction
1.8Å resolution

CFTR Associated Ligand (CAL) PDZ bound to HPV16 E6 oncoprotein C-terminal peptide (TRRETQL)

Released:

Function and Biology Details

Biochemical function:
  • not assigned
Cellular component:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Golgi-associated PDZ and coiled-coil motif-containing protein Chains: A, B
Molecule details ›
Chains: A, B
Length: 87 amino acids
Theoretical weight: 9.35 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q9HD26 (Residues: 284-370; Coverage: 19%)
Gene names: CAL, FIG, GOPC
Sequence domains: PDZ domain
Structure domains: Pdz3 Domain
Protein E6 Chains: C, D
Molecule details ›
Chains: C, D
Length: 7 amino acids
Theoretical weight: 905 Da
Source organism: Human papillomavirus type 16
Expression system: Not provided
UniProt:
  • Canonical: P03126 (Residues: 152-158; Coverage: 4%)
Gene name: E6

Ligands and Environments

No bound ligands

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X6A
Spacegroup: P21
Unit cell:
a: 33.083Å b: 48.396Å c: 51.966Å
α: 90° β: 101.55° γ: 90°
R-values:
R R work R free
0.181 0.179 0.219
Expression systems:
  • Escherichia coli BL21(DE3)
  • Not provided