PDBe 4jmg

X-ray diffraction
1.4Å resolution

Crystal structure of the synthetic protein in complex with pY peptide

Released:

Function and Biology Details

Reaction catalysed:
Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Clamp Ptpn11_pY580 Chain: A
Molecule details ›
Chain: A
Length: 203 amino acids
Theoretical weight: 22.19 KDa
Source organism: synthetic construct
Expression system: Escherichia coli
Tyrosine-protein phosphatase non-receptor type 11 Chain: B
Molecule details ›
Chain: B
Length: 13 amino acids
Theoretical weight: 1.56 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q06124 (Residues: 579-591; Coverage: 2%)
Gene names: PTP2C, PTPN11, SHPTP2

Ligands and Environments

1 bound ligand:

1 modified residue:

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 24-ID-C
Spacegroup: C2
Unit cell:
a: 109.597Å b: 34.402Å c: 47.799Å
α: 90° β: 105.22° γ: 90°
R-values:
R R work R free
0.176 0.174 0.206
Expression system: Escherichia coli