4jhr

X-ray diffraction
2.8Å resolution

An auto-inhibited conformation of LGN reveals a distinct interaction mode between GoLoco motifs and TPR motifs

Released:

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
G-protein-signaling modulator 2 Chains: A, B
Molecule details ›
Chains: A, B
Length: 333 amino acids
Theoretical weight: 36.88 KDa
Source organism: Mus musculus
Expression system: Escherichia coli
UniProt:
  • Canonical: Q8VDU0 (Residues: 96-357, 593-651; Coverage: 47%)
Gene names: Gpsm2, Lgn, Pins
Sequence domains:
Structure domains: Tetratricopeptide repeat domain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRF BEAMLINE BL17U
Unit cell:
a: 72.213Å b: 81.803Å c: 106.942Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.253 0.25 0.311
Expression system: Escherichia coli