4jdj

X-ray diffraction
2.3Å resolution

Crystal structure of Serine/threonine-protein kinase PAK 4 F461V mutant in complex with Paktide T peptide substrate

Released:

Function and Biology Details

Reaction catalysed:
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
Non-polymer only dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Serine/threonine-protein kinase PAK 4 Chain: A
Molecule details ›
Chain: A
Length: 346 amino acids
Theoretical weight: 39.16 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: O96013 (Residues: 286-591; Coverage: 52%)
Gene names: KIAA1142, PAK4
Sequence domains: Protein kinase domain
Structure domains:
Paktide T Chain: B
Molecule details ›
Chain: B
Length: 15 amino acids
Theoretical weight: 1.82 KDa
Source organism: Homo sapiens
Expression system: Not provided

Ligands and Environments

No bound ligands

2 modified residues:

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X25
Spacegroup: P41212
Unit cell:
a: 61.79Å b: 61.79Å c: 181.727Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.197 0.195 0.244
Expression systems:
  • Escherichia coli
  • Not provided