PDBe 4ilw

X-ray diffraction
2.1Å resolution

Complex of matrix metalloproteinase-10 catalytic domain (MMP-10cd) with tissue inhibitor of metalloproteinases-2 (TIMP-2)

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Metalloproteinase inhibitor 2 Chains: A, B
Molecule details ›
Chains: A, B
Length: 194 amino acids
Theoretical weight: 21.78 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P16035 (Residues: 27-220; Coverage: 100%)
Gene name: TIMP2
Structure domains:
Stromelysin-2 Chains: D, F
Molecule details ›
Chains: D, F
Length: 165 amino acids
Theoretical weight: 18.57 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P09238 (Residues: 99-263; Coverage: 36%)
Gene names: MMP10, STMY2
Sequence domains: Matrixin
Structure domains: Collagenase (Catalytic Domain)

Ligands and Environments

2 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X29A
Spacegroup: P1
Unit cell:
a: 37.687Å b: 56.934Å c: 82.592Å
α: 76.14° β: 79.84° γ: 71.25°
R-values:
R R work R free
0.219 0.216 0.263
Expression systems:
  • Homo sapiens
  • Escherichia coli BL21(DE3)