4iiq

X-ray diffraction
2.86Å resolution

Crystal structure of a human MAIT TCR in complex with bovine MR1

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
Non-polymer only trimer (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Ig-like domain-containing protein Chain: A
Molecule details ›
Chain: A
Length: 205 amino acids
Theoretical weight: 22.85 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q6P4G7 (Residues: 5-213; Coverage: 79%)
Gene name: TRA@
Sequence domains:
Structure domains: Immunoglobulins
T cell receptor beta constant 1 Chain: B
Molecule details ›
Chain: B
Length: 253 amino acids
Theoretical weight: 28.29 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P01850 (Residues: 1-129; Coverage: 73%)
Gene name: TRBC1
Sequence domains: Immunoglobulin C1-set domain
Structure domains: Immunoglobulins
Beta-2-microglobulin; Major histocompatibility complex class I-related gene protein Chain: C
Molecule details ›
Chain: C
Length: 392 amino acids
Theoretical weight: 45.42 KDa
Source organism: Bos taurus
Expression system: Trichoplusia ni
UniProt:
  • Canonical: C1ITJ8 (Residues: 19-295; Coverage: 87%)
  • Canonical: P01888 (Residues: 21-118; Coverage: 100%)
Gene names: B2M, MR1
Sequence domains:
Structure domains:

Ligands and Environments

1 bound ligand:

1 modified residue:

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 23-ID-D
Spacegroup: P212121
Unit cell:
a: 82.045Å b: 87.41Å c: 156.372Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.216 0.213 0.27
Expression systems:
  • Escherichia coli
  • Trichoplusia ni