X-ray diffraction
2.1Å resolution

Crystal Structure of human Bcl-2 in complex with a small molecule inhibitor targeting Bcl-2 BH3 domain interactions


Function and Biology Details

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Apoptosis regulator Bcl-2; Bcl-2-like protein 1 Chain: A
Molecule details ›
Chain: A
Length: 169 amino acids
Theoretical weight: 19.64 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
  • Canonical: P10415 (Residues: 1-34, 66-207; Coverage: 63%)
  • Canonical: Q07817 (Residues: 29-44; Coverage: 7%)
Gene names: BCL2, BCL2L, BCL2L1, BCLX
Sequence domains:

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X06SA
Spacegroup: P43212
Unit cell:
a: 73.529Å b: 73.529Å c: 96.205Å
α: 90° β: 90° γ: 90°
R R work R free
0.181 0.179 0.218
Expression system: Escherichia coli