› 4idw

X-ray powder diffraction

Polycrystalline T6 Bovine Insulin: Anisotropic Lattice Evolution and Novel Structure Refinement Strategy

Released:
DOI: 10.2210/pdb4idw/pdb
PDB entry 4idw coloured by chain, front view.
PDB entry 4idw coloured by chain, side view.
PDB entry 4idw coloured by chain, top view.
Source organism: Bos taurus
Primary publication:
High-resolution powder X-ray data reveal the T(6) hexameric form of bovine insulin.
Margiolaki I, Giannopoulou AE, Wright JP, Knight L, Norrman M, Schluckebier G, Fitch AN, Von Dreele RB
Acta Crystallogr D Biol Crystallogr 69 978-90 (2013)
PMID: 23695242

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero hexamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-134255 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Insulin A chain Chains: A, C
Molecule details ›
Chains: A, C
Length: 21 amino acids
Theoretical weight: 2.34 KDa
Source organism: Bos taurus
UniProt:
  • Canonical: P01317 (Residues: 85-105; Coverage: 26%)
Gene name: INS
Insulin B chain Chains: B, D
Molecule details ›
Chains: B, D
Length: 30 amino acids
Theoretical weight: 3.4 KDa
Source organism: Bos taurus
UniProt:
  • Canonical: P01317 (Residues: 25-54; Coverage: 37%)
Gene name: INS
Sequence domains: Insulin/IGF/Relaxin family

Ligands and Environments

1 bound ligand:
Ligand ZN 2 x ZN
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID13, null
Spacegroup: R3
Unit cell:
a: 82.607Å b: 82.607Å c: 33.632Å
α: 90° β: 90° γ: 120°

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Citations

1 review citation

Glycoscience@Synchrotron: Synchrotron radiation applied to structural glycoscience.
Pérez et al. (2017)
3 other articles

1 mention without citation

In Quest for Improved Drugs against Diabetes: The Added Value of X-ray Powder Diffraction Methods.
Karavassili et al. (2017)