4i2x

X-ray diffraction
2.48Å resolution

Crystal structure of Signal Regulatory Protein gamma (SIRP-gamma) in complex with FabOX117

Released:

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
FabOX117 light chain Chains: A, C
Molecule details ›
Chains: A, C
Length: 214 amino acids
Theoretical weight: 23.66 KDa
Source organism: Homo sapiens
Structure domains: Immunoglobulins
FabOX117 heavy chain Chains: B, D
Molecule details ›
Chains: B, D
Length: 229 amino acids
Theoretical weight: 24.77 KDa
Source organism: Homo sapiens
Structure domains: Immunoglobulins
Signal-regulatory protein gamma Chains: E, F
Molecule details ›
Chains: E, F
Length: 328 amino acids
Theoretical weight: 36.58 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q9P1W8 (Residues: 29-347; Coverage: 89%)
Gene names: SIRPB2, SIRPG
Sequence domains:
Structure domains: Immunoglobulins

Ligands and Environments

3 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I03
Spacegroup: P21212
Unit cell:
a: 140.361Å b: 174.191Å c: 81.734Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.199 0.196 0.26