4hwb

X-ray diffraction
2.61Å resolution

Crystal structure of ectodomain 3 of the IL-13 receptor alpha 1 in complex with a human neutralizing monoclonal antibody fragment

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Interleukin-13 receptor subunit alpha-1 Chain: A
Molecule details ›
Chain: A
Length: 122 amino acids
Theoretical weight: 14.65 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P78552 (Residues: 223-336; Coverage: 28%)
  • Best match: P78552-2 (Residues: 223-278)
Gene names: IL13R, IL13RA, IL13RA1
Structure domains: Immunoglobulins
Fab heavy chain Chain: H
Molecule details ›
Chain: H
Length: 227 amino acids
Theoretical weight: 24.34 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
Structure domains: Immunoglobulins
Fab light chain Chain: L
Molecule details ›
Chain: L
Length: 212 amino acids
Theoretical weight: 23.13 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
Structure domains: Immunoglobulins

Ligands and Environments

2 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: AUSTRALIAN SYNCHROTRON BEAMLINE MX2
Spacegroup: P4122
Unit cell:
a: 123.48Å b: 123.48Å c: 181.43Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.198 0.197 0.224
Expression system: Escherichia coli