X-ray diffraction
2Å resolution

Crystal Structure of Full-Length Human IFIT5 with 5`-triphosphate Oligouridine


Function and Biology Details

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
1 distinct RNA molecule
Macromolecules (2 distinct):
Interferon-induced protein with tetratricopeptide repeats 5 Chain: A
Molecule details ›
Chain: A
Length: 482 amino acids
Theoretical weight: 55.93 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
  • Canonical: Q13325 (Residues: 1-482; Coverage: 100%)
Gene names: IFIT5, ISG58, RI58
Sequence domains:
Structure domains: Tetratricopeptide repeat domain
RNA (5'-R(*(UTP)P*UP*UP*U)-3') Chain: X
Molecule details ›
Chain: X
Length: 4 nucleotides
Theoretical weight: 1.34 KDa
Source organism: Homo sapiens
Expression system: Not provided

Ligands and Environments

1 bound ligand:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU MICROMAX-007 HF
Spacegroup: P21
Unit cell:
a: 54.475Å b: 84.939Å c: 60.928Å
α: 90° β: 106.75° γ: 90°
R R work R free
0.177 0.175 0.207
Expression systems:
  • Escherichia coli
  • Not provided