X-ray diffraction
2.6Å resolution

Crystal structure of human Sirt5 in complex with Fluor-de-Lys peptide and resveratrol


Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assemblies composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
NAD-dependent protein deacylase sirtuin-5, mitochondrial Chains: A, B
Molecule details ›
Chains: A, B
Length: 275 amino acids
Theoretical weight: 29.91 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
  • Canonical: Q9NXA8 (Residues: 34-302; Coverage: 87%)
  • Best match: Q9NXA8-4 (Residues: 1-194)
Gene names: SIR2L5, SIRT5
Sequence domains: Sir2 family
Structure domains:
Fluor-de-Lys peptide Chain: F
Molecule details ›
Chain: F
Length: 4 amino acids
Theoretical weight: 770 Da
Source organism: Homo sapiens
Expression system: Not provided

Ligands and Environments

2 bound ligands:
1 modified residue:

Experiments and Validation Details

Entry percentile scores
X-ray source: OTHER
Spacegroup: P21
Unit cell:
a: 41.3Å b: 112.69Å c: 55.89Å
α: 90° β: 90.05° γ: 90°
R R work R free
0.205 0.199 0.252
Expression systems:
  • Escherichia coli BL21(DE3)
  • Not provided