X-ray diffraction
1.5Å resolution

Influenza N2-Tyr406Asp neuraminidase in complex with beta-Neu5Ac


Function and Biology Details

Reaction catalysed:
Hydrolysis of alpha-(2->3)-, alpha-(2->6)-, alpha-(2->8)- glycosidic linkages of terminal sialic acid residues in oligosaccharides, glycoproteins, glycolipids, colominic acid and synthetic substrates.
Biochemical function:
Cellular component:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Entry contents:
1 distinct polypeptide molecule
Neuraminidase Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 388 amino acids
Theoretical weight: 43.01 KDa
Source organism: Influenza A virus (A/RI/5+/1957(H2N2))
Expression system: Spodoptera frugiperda
  • Canonical: Q194T1 (Residues: 82-469; Coverage: 83%)
Gene name: NA
Sequence domains: Neuraminidase
Structure domains: Neuraminidase

Ligands and Environments

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRF BEAMLINE BL17U
Spacegroup: P21
Unit cell:
a: 83.217Å b: 114.831Å c: 84.259Å
α: 90° β: 99.71° γ: 90°
R R work R free
0.161 0.14 0.161
Expression system: Spodoptera frugiperda