4h22

X-ray diffraction
2.89Å resolution

Crystal structure of the dimeric coiled-coil domain of the cytosolic nucleic acid sensor LRRFIP1

Released:

Function and Biology Details

Biochemical function:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Leucine-rich repeat flightless-interacting protein 1 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 103 amino acids
Theoretical weight: 12.4 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q32MZ4 (Residues: 162-249; Coverage: 11%)
  • Best match: Q32MZ4-4 (Residues: 290-377)
Gene names: GCF2, LRRFIP1, TRIP
Structure domains: Single alpha-helices involved in coiled-coils or other helix-helix interfaces

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X29A
Spacegroup: C2
Unit cell:
a: 152.363Å b: 71.447Å c: 68.035Å
α: 90° β: 110.1° γ: 90°
R-values:
R R work R free
0.235 0.235 0.248
Expression system: Escherichia coli