PDBe 4giq

X-ray diffraction
2.7Å resolution

Crystal Structure of mouse RANK bound to RANKL


Function and Biology Details

Structure analysis Details

Assembly composition:
hetero hexamer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Tumor necrosis factor ligand superfamily member 11, soluble form Chain: A
Molecule details ›
Chain: A
Length: 171 amino acids
Theoretical weight: 19.06 KDa
Source organism: Mus musculus
Expression system: Escherichia coli BL21(DE3)
  • Canonical: O35235 (Residues: 158-316; Coverage: 50%)
Gene names: Opgl, Rankl, Tnfsf11, Trance
Sequence domains: TNF(Tumour Necrosis Factor) family
Structure domains: Jelly Rolls
Tumor necrosis factor receptor superfamily member 11A Chain: R
Molecule details ›
Chain: R
Length: 174 amino acids
Theoretical weight: 19.03 KDa
Source organism: Mus musculus
Expression system: unidentified baculovirus
  • Canonical: O35305 (Residues: 31-198; Coverage: 28%)
Gene names: Rank, Tnfrsf11a
Sequence domains:
Structure domains: Tumor Necrosis Factor Receptor, subunit A, domain 2

Ligands and Environments

3 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU RUH3R
Spacegroup: P63
Unit cell:
a: 120.636Å b: 120.636Å c: 94.297Å
α: 90° β: 90° γ: 120°
R R work R free
0.191 0.188 0.216
Expression systems:
  • Escherichia coli BL21(DE3)
  • unidentified baculovirus