4gae

X-ray diffraction
2.3Å resolution

Crystal structure of plasmodium dxr in complex with a pyridine-containing inhibitor

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
1-deoxy-D-xylulose 5-phosphate reductoisomerase, apicoplastic Chains: A, B
Molecule details ›
Chains: A, B
Length: 426 amino acids
Theoretical weight: 48.54 KDa
Source organism: Plasmodium falciparum HB3
Expression system: Escherichia coli
UniProt:
  • Canonical: O96693 (Residues: 75-488; Coverage: 85%)
Gene name: DXR
Sequence domains:
Structure domains:

Ligands and Environments


Cofactor: Ligand NDP 2 x NDP
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU FR-E+ SUPERBRIGHT
Spacegroup: P21
Unit cell:
a: 51.36Å b: 77.28Å c: 109.41Å
α: 90° β: 91.5° γ: 90°
R-values:
R R work R free
0.23 0.23 0.273
Expression system: Escherichia coli