PDBe 4g3f

X-ray diffraction
1.64Å resolution

Crystal structure of murine NF-kappaB inducing kinase (NIK) bound to a 2-(aminothiazoly)phenol (cmp2)

Released:

Function and Biology Details

Reaction catalysed:
ATP + a protein = ADP + a phosphoprotein. 
Biochemical function:
Biological process:
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Mitogen-activated protein kinase kinase kinase 14 Chain: A
Molecule details ›
Chain: A
Length: 336 amino acids
Theoretical weight: 36.98 KDa
Source organism: Mus musculus
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q9WUL6 (Residues: 345-675; Coverage: 35%)
Gene names: Map3k14, Nik
Sequence domains: Protein kinase domain
Structure domains: Transferase(Phosphotransferase) domain 1

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 5.0.1
Spacegroup: C2221
Unit cell:
a: 74.789Å b: 135.619Å c: 64.857Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.18 0.177 0.208
Expression system: Spodoptera frugiperda