4fv5

X-ray diffraction
2.4Å resolution

Crystal Structure of the ERK2 complexed with EK9

Released:
Source organism: Homo sapiens
Entry authors: Kang YN, Stuckey JA, Xie X

Function and Biology Details

Reaction catalysed:
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Cellular component:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Mitogen-activated protein kinase 1 Chain: A
Molecule details ›
Chain: A
Length: 360 amino acids
Theoretical weight: 41.52 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P28482 (Residues: 1-360; Coverage: 100%)
Gene names: ERK2, MAPK1, PRKM1, PRKM2
Sequence domains: Protein kinase domain
Structure domains:

Ligands and Environments

3 bound ligands:
1 modified residue:

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU
Spacegroup: P212121
Unit cell:
a: 43.97Å b: 71.07Å c: 118.58Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.206 0.204 0.248
Expression system: Escherichia coli