4flp

X-ray diffraction
2.23Å resolution

Crystal Structure of the first bromodomain of human BRDT in complex with the inhibitor JQ1

Released:

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Bromodomain testis-specific protein Chains: A, B
Molecule details ›
Chains: A, B
Length: 119 amino acids
Theoretical weight: 14.17 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q58F21 (Residues: 21-137; Coverage: 12%)
  • Best match: Q58F21-5 (Residues: 1-64)
Gene name: BRDT
Sequence domains: Bromodomain
Structure domains: Bromodomain-like

Ligands and Environments

2 bound ligands:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I03
Unit cell:
a: 37.4Å b: 57.42Å c: 128.69Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.213 0.211 0.255
Expression system: Escherichia coli