PDBe 4fe8

X-ray diffraction
3Å resolution

Crystal Structure of Htt36Q3H-EX1-X1-C1(Alpha)

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
homo trimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Huntingtin; Maltose/maltodextrin-binding periplasmic protein Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 452 amino acids
Theoretical weight: 50.11 KDa
Source organisms: Expression system: Escherichia coli BL21
UniProt:
  • Canonical: P42858 (Residues: 1-17, 18-64; Coverage: 2%)
  • Canonical: P0AEX9 (Residues: 27-384; Coverage: 97%)
  • nullnull
Gene names: HD, HTT, IT15, JW3994, b4034, malE
Sequence domains: Bacterial extracellular solute-binding protein
Structure domains: Periplasmic binding protein-like II

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 19-ID
Spacegroup: C2
Unit cell:
a: 155.052Å b: 177.278Å c: 78.868Å
α: 90° β: 109.03° γ: 90°
R-values:
R R work R free
0.229 0.227 0.275
Expression system: Escherichia coli BL21