4f95

X-ray diffraction
2.07Å resolution

Crystal structure of human inosine triphosphate pyrophosphatase P32T variant

Released:

Function and Biology Details

Reaction catalysed:
A nucleoside triphosphate + H(2)O = a nucleotide + diphosphate
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Inosine triphosphate pyrophosphatase Chain: A
Molecule details ›
Chain: A
Length: 197 amino acids
Theoretical weight: 21.75 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q9BY32 (Residues: 1-194; Coverage: 100%)
Gene names: C20orf37, ITPA, My049, OK/SW-cl.9
Sequence domains: Ham1 family
Structure domains: Maf protein

Ligands and Environments

No bound ligands

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU FR-E SUPERBRIGHT
Spacegroup: P21212
Unit cell:
a: 31.02Å b: 104.42Å c: 50.36Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.237 0.234 0.308
Expression system: Escherichia coli BL21(DE3)