X-ray diffraction
1.9Å resolution

Crystal Structure of Calmodulin Binding Domain of Orai1 in Complex with Ca2+/Calmodulin Displays a Unique Binding Mode


Function and Biology Details

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Calmodulin-1 Chain: A
Molecule details ›
Chain: A
Length: 148 amino acids
Theoretical weight: 16.72 KDa
Source organism: Rattus norvegicus
Expression system: Escherichia coli
  • Canonical: P0DP29 (Residues: 2-149; Coverage: 99%)
Gene names: CaMI, Calm, Calm1, Cam, Cam1
Sequence domains: EF-hand domain pair
Calcium release-activated calcium channel protein 1 Chain: G
Molecule details ›
Chain: G
Length: 20 amino acids
Theoretical weight: 2.39 KDa
Source organism: Homo sapiens
Expression system: Not provided
  • Canonical: Q96D31 (Residues: 69-88; Coverage: 7%)
Gene names: CRACM1, ORAI1, TMEM142A

Ligands and Environments

2 bound ligands:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU MICROMAX-007 HF
Spacegroup: C2
Unit cell:
a: 100.074Å b: 24.709Å c: 60.903Å
α: 90° β: 100.1° γ: 90°
R R work R free
0.181 0.179 0.216
Expression systems:
  • Escherichia coli
  • Not provided