PDBe 4dx9

X-ray diffraction
2.99Å resolution

ICAP1 in complex with integrin beta 1 cytoplasmic tail

Released:

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assemblies composition:
hetero dimer (preferred)
monomeric
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Integrin beta-1 Chains: 6, 7, 8, 9, B, D, F, H, J, L, N, P, R, T, V, X, Z, b, d, f, h, j, l, n, p, r, t, v, x, z
Molecule details ›
Chains: 6, 7, 8, 9, B, D, F, H, J, L, N, P, R, T, V, X, Z, b, d, f, h, j, l, n, p, r, t, v, x, z
Length: 15 amino acids
Theoretical weight: 1.62 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P05556 (Residues: 784-798; Coverage: 2%)
Gene names: FNRB, ITGB1, MDF2, MSK12
Integrin beta-1-binding protein 1 Chains: 0, 1, 2, 3, 4, 5, A, C, E, G, I, K, M, O, Q, S, U, W, Y, a, c, e, g, i, k, m, o, q, s, u, w, y
Molecule details ›
Chains: 0, 1, 2, 3, 4, 5, A, C, E, G, I, K, M, O, Q, S, U, W, Y, a, c, e, g, i, k, m, o, q, s, u, w, y
Length: 157 amino acids
Theoretical weight: 17.27 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: O14713 (Residues: 49-200; Coverage: 76%)
Gene names: ICAP1, ITGB1BP1
Structure domains: Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)

Ligands and Environments

No bound ligands

1 modified residue:

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X25
Spacegroup: P1
Unit cell:
a: 75.622Å b: 122.207Å c: 135.269Å
α: 89.97° β: 89.99° γ: 108.11°
R-values:
R R work R free
0.255 0.251 0.312
Expression systems:
  • Not provided
  • Escherichia coli