PDBe 4dx8

X-ray diffraction
2.54Å resolution

ICAP1 in complex with KRIT1 N-terminus

Released:

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Integrin beta-1-binding protein 1 Chains: A, B, D, E
Molecule details ›
Chains: A, B, D, E
Length: 154 amino acids
Theoretical weight: 16.91 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: O14713 (Residues: 49-200; Coverage: 76%)
Gene names: ICAP1, ITGB1BP1
Structure domains: Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)
Krev interaction trapped protein 1 Chains: H, I, J, K
Molecule details ›
Chains: H, I, J, K
Length: 203 amino acids
Theoretical weight: 22.91 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: O00522 (Residues: 1-198; Coverage: 27%)
Gene names: CCM1, KRIT1
Sequence domains: NUDIX, or N-terminal NPxY motif-rich, region of KRIT
Structure domains: Alpha-Beta Plaits

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X25
Spacegroup: C2221
Unit cell:
a: 153.898Å b: 157.977Å c: 152.006Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.222 0.22 0.252
Expression system: Escherichia coli BL21(DE3)