› 4dqo

X-ray diffraction
2.44Å resolution

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-212412 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (5 distinct):
PG16 Fab Heavy Chain Chain: H
Molecule details ›
Chain: H
Length: 246 amino acids
Theoretical weight: 26.83 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
Structure domains: Immunoglobulins
PG16 Fab Light Chain Chain: L
Molecule details ›
Chain: L
Length: 216 amino acids
Theoretical weight: 22.71 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
Structure domains: Immunoglobulins
Envelope glycoprotein gp160 Chain: C
Molecule details ›
Chain: C
Length: 124 amino acids
Theoretical weight: 13.49 KDa
Source organism: Human immunodeficiency virus 1
Expression system: Homo sapiens
UniProt:
  • Canonical: Q6TCP8 (Residues: 125-216; Coverage: 11%)
Gene name: env
Structure domains: Ubiquitin-like (UB roll)

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG, BMA, MAN
Carbohydrate polymer
Carbohydrate polymer : NEW Components: NAG, BMA, MAN, GAL, SIA
Carbohydrate polymer
No bound ligands
2 modified residues:
Ligand PCA 1 x PCA
Ligand TYS 1 x TYS

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 22-ID
Spacegroup: C2221
Unit cell:
a: 81.054Å b: 207.561Å c: 87.617Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.203 0.201 0.23
Expression system: Homo sapiens

Quick links

Citations

42 review citations

Structural insights on the role of antibodies in HIV-1 vaccine and therapy.
West et al. (2014)
41 more

15 mentions without citation

Crystal structure of a soluble cleaved HIV-1 envelope trimer.
Julien et al. (2013)
14 more