4dhx

X-ray diffraction
2.1Å resolution

Function and Biology Details

Reaction catalysed:
Acetyl-CoA + [protein]-L-lysine = CoA + [protein]-N(6)-acetyl-L-lysine
Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Germinal-center associated nuclear protein Chains: A, D
Molecule details ›
Chains: A, D
Length: 75 amino acids
Theoretical weight: 8.56 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: O60318 (Residues: 1163-1235; Coverage: 4%)
Gene names: GANP, KIAA0572, MAP80, MCM3AP
Sequence domains: Binding region of GANP to ENY2
Structure domains: Single alpha-helices involved in coiled-coils or other helix-helix interfaces
Transcription and mRNA export factor ENY2 Chains: B, C, E, F
Molecule details ›
Chains: B, C, E, F
Length: 101 amino acids
Theoretical weight: 11.55 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9NPA8 (Residues: 1-101; Coverage: 100%)
Gene names: DC6, ENY2
Sequence domains: Transcription factor e(y)2
Structure domains: Serum Albumin; Chain A, Domain 1

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU FR-E+ DW
Spacegroup: P21
Unit cell:
a: 68.592Å b: 76.124Å c: 70.612Å
α: 90° β: 117.69° γ: 90°
R-values:
R R work R free
0.224 0.222 0.25
Expression system: Escherichia coli