PDBe 4cue

X-ray diffraction
3Å resolution

Human Notch1 EGF domains 11-13 mutant T466V

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Neurogenic locus notch homolog protein 1 Chain: A
Molecule details ›
Chain: A
Length: 135 amino acids
Theoretical weight: 14.86 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P46531 (Residues: 411-526; Coverage: 5%)
Gene names: NOTCH1, TAN1
Sequence domains:
Structure domains: Laminin

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I02
Spacegroup: P6122
Unit cell:
a: 63.78Å b: 63.78Å c: 127.27Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.261 0.26 0.282
Expression system: Escherichia coli