PDBe 4cru

X-ray diffraction
1.65Å resolution

Complex of human CNOT9 and CNOT1 including one tryptophan

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
CCR4-NOT transcription complex subunit 1 Chain: A
Molecule details ›
Chain: A
Length: 258 amino acids
Theoretical weight: 29.17 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: A5YKK6 (Residues: 1356-1607; Coverage: 11%)
Gene names: AD-005, CDC39, CNOT1, KIAA1007, NOT1
Sequence domains: Domain of unknown function (DUF3819)
CCR4-NOT transcription complex subunit 9 Chain: B
Molecule details ›
Chain: B
Length: 273 amino acids
Theoretical weight: 31.07 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q92600 (Residues: 19-285; Coverage: 89%)
Gene names: CNOT9, RCD1, RQCD1
Sequence domains: Cell differentiation family, Rcd1-like
Structure domains: Leucine-rich Repeat Variant

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X10SA
Spacegroup: C2
Unit cell:
a: 154.8Å b: 67.24Å c: 72.3Å
α: 90° β: 99.64° γ: 90°
R-values:
R R work R free
0.161 0.16 0.179
Expression system: Escherichia coli BL21(DE3)