PDBe 4byf

X-ray diffraction
2.74Å resolution

Crystal structure of human Myosin 1c in complex with calmodulin in the pre-power stroke state

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Unconventional myosin-Ic Chains: A, C
Molecule details ›
Chains: A, C
Length: 725 amino acids
Theoretical weight: 83.94 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: O00159 (Residues: 36-760; Coverage: 68%)
Gene name: MYO1C
Sequence domains:
Calmodulin-2 Chains: B, D
Molecule details ›
Chains: B, D
Length: 149 amino acids
Theoretical weight: 16.85 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P0DP24 (Residues: 1-149; Coverage: 100%)
Gene names: CALM2, CAM2, CAMB
Sequence domains: EF-hand domain pair

Ligands and Environments

2 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID23-1
Spacegroup: P21
Unit cell:
a: 59.58Å b: 158.45Å c: 114.34Å
α: 90° β: 91.56° γ: 90°
R-values:
R R work R free
0.183 0.183 0.237
Expression system: Spodoptera frugiperda