PDBe 4bxl

Solution NMR

Structure of alpha-synuclein in complex with an engineered binding protein


Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
AS69 Chains: A, B
Molecule details ›
Chains: A, B
Length: 46 amino acids
Theoretical weight: 5.09 KDa
Source organism: synthetic construct
Expression system: Escherichia coli BL21(DE3)
Structure domains: Immunoglobulin FC, subunit C
Alpha-synuclein Chain: C
Molecule details ›
Chain: C
Length: 22 amino acids
Theoretical weight: 2.2 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
  • Canonical: P37840 (Residues: 35-56; Coverage: 16%)
Gene names: NACP, PARK1, SNCA

Ligands and Environments

No bound ligands

No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 89%
Refinement method: simulated annealing
Expression system: Escherichia coli BL21(DE3)