4b7w

X-ray diffraction
4Å resolution

Ligand binding domain human hepatocyte nuclear factor 4alpha: Apo form

Released:
Source organism: Homo sapiens
Entry authors: Dudasova Z, Okvist M, Kretova M, Ondrovicova G, Skrabana R, LeGuevel R, Salbert G, Leonard G, McSweeney S, Barath P

Function and Biology Details

Structure analysis Details

Assembly composition:
homo octamer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Hepatocyte nuclear factor 4-alpha Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 239 amino acids
Theoretical weight: 26.92 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P41235 (Residues: 142-377; Coverage: 50%)
Gene names: HNF4, HNF4A, NR2A1, TCF14
Sequence domains: Ligand-binding domain of nuclear hormone receptor
Structure domains: Retinoid X Receptor

Ligands and Environments

No bound ligands

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID23-2
Spacegroup: P21212
Unit cell:
a: 101.048Å b: 105.282Å c: 98.322Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.25 0.25 0.28
Expression system: Escherichia coli BL21(DE3)