4aym

X-ray diffraction
3Å resolution

Structure of a complex between CCPs 6 and 7 of Human Complement Factor H and Neisseria meningitidis FHbp Variant 3 P106A mutant

Released:

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assemblies composition:
hetero dimer (preferred)
monomeric
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Complement factor H Chains: A, B, E, F
Molecule details ›
Chains: A, B, E, F
Length: 125 amino acids
Theoretical weight: 14.41 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli B
UniProt:
  • Canonical: P08603 (Residues: 321-443; Coverage: 10%)
Gene names: CFH, HF, HF1, HF2
Sequence domains: Sushi repeat (SCR repeat)
Structure domains: Complement Module, domain 1
Lipoprot_C domain-containing protein Chains: C, D
Molecule details ›
Chains: C, D
Length: 270 amino acids
Theoretical weight: 29.49 KDa
Source organism: Neisseria meningitidis MC58
Expression system: Escherichia coli B
UniProt:
  • Canonical: Q19KF7 (Residues: 32-281; Coverage: 95%)
Gene name: gna1870
Sequence domains: Lipoprotein GNA1870 C terminal like
Structure domains:

Ligands and Environments

No bound ligands

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I04
Spacegroup: C2221
Unit cell:
a: 78.09Å b: 83.49Å c: 361.43Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.254 0.254 0.257
Expression system: Escherichia coli B