4ayd

X-ray diffraction
2.4Å resolution

Structure of a complex between CCPs 6 and 7 of Human Complement Factor H and Neisseria meningitidis FHbp Variant 1 R106A mutant

Released:

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Complement factor H Chains: A, B, E
Molecule details ›
Chains: A, B, E
Length: 125 amino acids
Theoretical weight: 14.41 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P08603 (Residues: 321-443; Coverage: 10%)
Gene names: CFH, HF, HF1, HF2
Sequence domains: Sushi repeat (SCR repeat)
Structure domains: Complement Module, domain 1
Lipoprot_C domain-containing protein Chains: C, D, F
Molecule details ›
Chains: C, D, F
Length: 257 amino acids
Theoretical weight: 27.61 KDa
Source organism: Neisseria meningitidis MC58
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9JXV4 (Residues: 73-320; Coverage: 78%)
Gene name: NMB1870
Sequence domains: Lipoprotein GNA1870 C terminal like
Structure domains:

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID29
Spacegroup: C2
Unit cell:
a: 185.26Å b: 54.01Å c: 129.56Å
α: 90° β: 118.03° γ: 90°
R-values:
R R work R free
0.204 0.202 0.231
Expression system: Escherichia coli